GLPG3312 [2340388-72-7]

TargetMol Chemicals

GLPG3312 [2340388-72-7]

16

Research Use Only

C23H21F2N5O3

453.44

GLPG3312 (Compound 28), characterized as a selective pan-SIK inhibitor, exhibits IC50 values of 2.0 nM for SIK1, 0.7 nM for SIK2, and 0.6 nM for SIK3. Demonstrating both anti-inflammatory and immunomodulatory activities, this compound effectively targets human primary myeloid cells in vitro and mouse models in vivo. With favorable oral bioavailability, GLPG3312 serves as a promising agent for the study of inflammatory and immune diseases [1].

O(C(F)F)C=1C=C(C=C(OC)C1C(NC2CC2)=O)N3C=4C(N=C3)=CC(=CC4)C=5C=NN(C)C5

-20°C

12352200