GNE-3500 [1537859-24-7]

MedChem Express

GNE-3500 [1537859-24-7]

5

1537859-24-7

Research Use Only

C24H30FN3O3S

459.58

GNE-3500 is a selective, orally active antagonist for Retinoic Acid Receptor-Related Orphan Receptor C (RORc, also known as RORgamma or NR1F3) with an EC50 of 12 nM. GNE-3500 exhibits good pharmacokinetic characteristics in rats[1].

FC1=CC(N2CCN(C(C)=O)CC2)=CC=C1CN3[C@@H](C)CC[C@H](C4=CC=CC=C4)S3(=O)=O

12352200