GNE-490 [1033739-92-2]

SYNkinase

GNE-490 [1033739-92-2]

10

1033739-92-2

Research Use Only

>95%

C18H22N6O2S

386.5

Chemical. CAS: 1033739-92-2. Formula: C18H22N6O2S. MW: 386.5. GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR. It has good pharmacokinetic (PK) parameters and demonstrates knock down of pathway markers in vivo. Originally obtained via modification of compounds like GDC-0941, GNE-490 which have a significantly reduced potency mTOR while maintaining effective potency for PI3K substrates. IC(50) values for PI3K family members are in the subnanomolar to low nanomolar range (-.28 to <20nm) while IC(50) values for mTOR and other related tyrosine kinases are greater than 750nM with most being greater than 1microM or more, thus GNE-490 makes a good choice for examining PI3K related events separate from those mediated by mTOR. - GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR. It has good pharmacokinetic (PK) parameters and demonstrates knock down of pathway markers in vivo. Originally obtained via modification of compounds like GDC-0941, GNE-490 which have a significantly reduced potency mTOR while maintaining effective potency for PI3K substrates. IC(50) values for PI3K family members are in the subnanomolar to low nanomolar range (-.28 to < 20nm) while IC(50) values for mTOR and other related tyrosine kinases are greater than 750nM with most being greater than 1microM or more, thus GNE-490 makes a good choice for examining PI3K related events separate from those mediated by mTOR.

2°C to 8°C,-20°C

12352200