GNE-7883

MedChem Express

GNE-7883

5

Research Use Only

99.54

C28H29FN6O2

500.57

GNE-7883 is a pan- TEAD inhibitor that blocks the association of YAP/TAZ with TEAD . GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation [1] [2] [3] .

O=C(C=C(C1=CC=C(C2CCCCC2)C=C1)N3)N4C3=C(C(N5CC(CF)C5)=O)C(C6=NC=CN=C6C)=N4

-20°C,2°C to 8°C

12352200