GNF 5837 [1033769-28-6]

Biorbyt

GNF 5837 [1033769-28-6]

16

1033769-28-6

Research Use Only

C28H21F4N5O2

535.4923

GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively).

FC1C([H])=C([H])C(C(F)(F)F)=C([H])C=1N([H])C(N([H])C1C([H])=C([H])C(C([H])([H])[H])=C(C=1[H])N([H])C1C([H])=C([H])C2/C(=C(\[H])/C3=C([H])C([H])=C([H])N3[H])/C(N([H])C=2C=1[H])=O)=O

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