GNF-6 [839708-29-1]

TargetMol Chemicals

GNF-6 [839708-29-1]

16

Research Use Only

C22H19F3N6O2

456.42

GNF-6 (Compound 14), an ATP competitive inhibitor, inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50 values of 0.25 microM for c-ABL-T334I, 0.09 microM for BCR-ABL, and 0.590 microM for BCR-ABL-T315I variants. It disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), locking the kinase in an inactive DFG-out conformation [1].

O=C1N(CC=2C(N1C)=NC(N)=NC2)C3=CC(NC(=O)C4=CC(C(F)(F)F)=CC=C4)=CC=C3C

-20°C

12352200