GP IIb/IIIa antibody [237]

GeneTex

GP IIb/IIIa antibody [237]

9

Under reducing conditions, this antibody will bind against the human platelet membrane glycoproteins IIb and/or IIIa, which have molecular weights of ~130,000 (IIb) and 115,000 (IIIa).

This antibody, used at a concentration of 10-20microg/mL will allow visualization of NP 40 solubized normal human platelets

Western Blot

Research Use Only

Monoclonal

237

1 mg/ml

Unconjugated

Mouse

IgG1

The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated alpha and beta subunits. CD61 non-covalently associates with CD41 (alpha Ilb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation.

Human

-20°C or -80°C,2°C to 8°C

12352203