GPAM antibody

GeneTex

GPAM antibody

9

At least four isoforms are known to exist; this antibody will detect only the two largest isoforms.

WB: 1 - 2 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

GPAM

glycerol-3-phosphate acyltransferase, mitochondrial

glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT; GPAT1; GPAT-1

Rabbit

IgG

Glycerol-3-phosphate acyltransferase 1, mitochondrial

Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203