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GPI-15427 [805242-85-7]
T68663
Overview
- SupplierTargetMol Chemicals
- Product NameGPI-15427 [805242-85-7]
- Delivery Days Customer72
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameGPI-15427
- Molecular FormulaC20H20N4O2
- Molecular Weight348.4
- Scientific DescriptionGPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC.
- Shelf life instruction3 years
- SMILESO=C1C2=C3C(C=4C(OC3=CC=C2)=CC=C(CN5CCN(C)CC5)C4)=NN1
- Storage Instruction-20°C
- UNSPSC12352200