GPR183 antagonist-2

MedChem Express

GPR183 antagonist-2

14

Research Use Only

99.96

C20H18F2N4O5

432.38

GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases [1] .

FC(O1)(F)OC2=C1C=CC(/C=C/C(N3CCN(C(C4=CN=C(OC)N=C4)=O)CC3)=O)=C2

-20°C,2°C to 8°C

12352200