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GPX3 (human) ELISA Kit

Research Use Only
AG-45A-0020YTP
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    GPX3 (human) ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.5 to 32ng/ml
  • Assay Sensitivity
    100pg/ml
  • Assay Specificity
    Detects human GPX3.
  • Certification
    Research Use Only
  • Scientific Description
    ELISA Assay. Detects human GPX3. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 0.5 to 32ng/ml. Sensitivity: 100pg/ml. Glutathione peroxidase 3 (GPX3; GSHPX3) is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The activity of GPX3 is significantly reduced in the plasma and tissue of cancer patients. Recently, GPX3 was suggested to serve as a molecular marker for the diagnosis of clear cell type ovarian adenocarcinoma. - Glutathione peroxidase 3 (GPX3; GSHPX3) is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The activity of GPX3 is significantly reduced in the plasma and tissue of cancer patients. Recently, GPX3 was suggested to serve as a molecular marker for the diagnosis of clear cell type ovarian adenocarcinoma.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Dysregulation of Adipose Glutathione Peroxidase 3 in Obesity Contributes to Local and Systemic Oxidative Stress: Y.S. Lee, et al.; Mol. Endocrinol. 22, 2176 (2008)
  • Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells: S.S. Chung, et al.; Mol. Cell Biol. 29, 20 (2009)
  • Oxidative stress after antenatal betamethasone: Acute downregulation of glutathione peroxidase-3: J. Verhaeghe, et al.; Early Hum. Dev. 85, 767 (2009)
  • Oxidant balance markers at birth in relation to glycemicand acid-base parameters: J. Verhaeghe, et al.; Metabolism 60, 71 (2011)
  • Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation: R. Lobb; University Waikato (Thesis) (2011) [http://hdl.handle.net/10289/5709]
  • Decreased levels of serum glutathione peroxidase 3 are associated with papillary serous ovarian cancer and disease progression: D. Agnani, et al.; J. Ovarian Res. 4, 18 (2011)
  • Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014)