Granzyme B (NK/T-Cell Lymphoma Marker)(GZMB/3014), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

Granzyme B (NK/T-Cell Lymphoma Marker)(GZMB/3014), CF594 conjugate, 0.1mg/mL

9

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

GZMB/3014

0.1 mg/ml

Other Conjugate

CEBPB

CCAAT enhancer binding protein beta

C/EBP-beta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; IL6DBP; interleukin 6-dependent DNA-binding protein; NF-IL6; nuclear factor NF-IL6; nuclear factor of interleukin 6; TCF5; transcription factor 5; transcription factor C/EBP beta

Mouse

IgG2b

Granzyme B

Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkins Disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Human

2°C to 8°C

12352203