Grapiprant

MedChem Express

Grapiprant [415903-37-6]

10

415903-37-6

Research Use Only

99.57

C26H29N5O3S

491.61

Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E 2 (PGE 2 ). Grapiprant displaces [ 3 H]-PGE 2 (1 nM) binding to dog recombinant EP4 receptor with IC 50 value of 35 nM and K i value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment [1] [2] [3] .

O=S(C1=CC=C(C)C=C1)(NC(NCCC2=CC=C(N3C(CC)=NC4=C3C=C(C)N=C4C)C=C2)=O)=O

-20°C,2°C to 8°C

12352200