Bio-Connect

GRIA2 Recombinant Monoclonal Antibody

CSB-RA009899A0HU
Cusabio
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetGRIA2
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Overview

  • Supplier
    Cusabio
  • Product Name
    GRIA2 Recombinant Monoclonal Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    4C7
  • Conjugate
    Unconjugated
  • Gene ID2891
  • Target name
    GRIA2
  • Target description
    glutamate ionotropic receptor AMPA type subunit 2
  • Target synonyms
    AMPA-selective glutamate receptor 2; GluA2; GLUR2; gluR-2; GLURB; gluR-B; GluR-K2; glutamate receptor 2; glutamate receptor, ionotropic, AMPA 2; HBGR2; NEDLIB
  • Isotype
    IgG
  • Protein IDP42262
  • Protein Name
    Glutamate receptor 2
  • Scientific Description
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203