GRIA2 Recombinant Monoclonal Antibody
CSB-RA009899A0HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetGRIA2
Overview
- SupplierCusabio
- Product NameGRIA2 Recombinant Monoclonal Antibody
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID4C7
- ConjugateUnconjugated
- Gene ID2891
- Target nameGRIA2
- Target descriptionglutamate ionotropic receptor AMPA type subunit 2
- Target synonymsAMPA-selective glutamate receptor 2; GluA2; GLUR2; gluR-2; GLURB; gluR-B; GluR-K2; glutamate receptor 2; glutamate receptor, ionotropic, AMPA 2; HBGR2; NEDLIB
- IsotypeIgG
- Protein IDP42262
- Protein NameGlutamate receptor 2
- Scientific DescriptionReceptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203