GSK 3008348

MedChem Express

GSK 3008348

9

1629249-33-7

Research Use Only

99.27

C29H37N5O2

487.64

GSK 3008348 is a small molecule integrin alphavbeta6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for Integrin Antagonist 1 was 8.1, whereas its affinity in the cell Adhesion Assays was for: alphanubeta6 (pIC50 = 8.4); alphanubeta3 (pIC50 = 6); alphanubeta5 (pIC50 = 6.9); alphanubeta8 (pIC50 = 7.7).

O=C(O)C[C@@H](C1=CC(N2N=C(C)C=C2C)=CC=C1)CN3C[C@H](CCC(N4)=CC=C5C4=NCCC5)CC3

-20°C,2°C to 8°C

12352200