GSK-3beta inhibitor 13
HY-149054
Molecular Weight414.46
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameGSK-3beta inhibitor 13
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC23H22N6O2
- Molecular Weight414.46
- Scientific DescriptionGSK-3beta inhibitor 13 (compound 47) is an orally active and potent GSK-3beta inhibitor with blood-brain permeability. GSK-3beta inhibitor 13 inhibits GSK-3beta and GSK-3alpha with IC50s of 0.73 nM and 0.35 nM, respectively. GSK-3beta inhibitor 13 significantly decreases the phosphorylation of tau (IC50=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimers disease.
- SMILESO=C(C1=CC=NN2C1=NC(C3=CC=CC=C3)=C2)NC4=C(C=CN=C4)N5CCOC(C5)C
- Storage InstructionSee Manual
- UNSPSC12352200