GSK-3beta inhibitor 17 [2521624-67-7]

TargetMol Chemicals

GSK-3beta inhibitor 17 [2521624-67-7]

9

Research Use Only

C26H18F3N5O6S2

617.58

GSK-3beta Inhibitor 17 (compound 5 n) reduces the expression of p-p65 and KIM-1 proteins in a dose-dependent manner (16, 32, 64 microM) induced by cisplatin. Additionally, at a concentration of 32 microM, it decreases the levels of TNF-alpha, IL-1beta, IL-6, and MCP-1 mRNA in an acute kidney injury (AKI) model of HK-2 cells triggered by cisplatin.

O=C(OC)C=1SC(=CC1)S(=O)(=O)NC=2C=CC(=CC2)C3=NC(=NO3)C=4C=CN=C(C4)NC5=CC=C(OC(F)(F)F)C=C5

-20°C

51202000