GSK1733953A [930470-97-6]

TargetMol Chemicals

GSK1733953A [930470-97-6]

9

Chemical

Research Use Only

GSK1733953A

99.45%

C21H17ClFNO3

385.82

GSK1733953A can be used as a small molecule Mycobacterium tuberculosis respiration inhibitor with an inhibitory effect on MenG activity and an IC50 value of 2.6 +/- 0.6 microM.GSK1733953A is a selective biphenylbenzamide with an inhibitory effect on the catalytic methylation of the Mycobacterium tuberculosis desmethylnaphthoquinone methyltransferase, and the MIC of GSK1733953A against Mycobacterium tuberculosis H4Rv was 8.37 microg/ml. MIC of 8.37 microg/ml and MIC of 1.2 to 9.6 microg/ml against drug-resistant strains.GSK1733953A is a candidate compound for the treatment of tuberculosis.

3 years

O(C)C1=C(C=C(NC(=O)C2=C(Cl)C=C(F)C=C2)C=C1)C3=CC=C(OC)C=C3

-20°C

12352200