GSK256471 [1133706-08-7]

TargetMol Chemicals

GSK256471 [1133706-08-7]

86

Chemical

Research Use Only

GSK256471

C29H29N3O3S

499.62

GSK256471 is a potent selective NK(3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK(3) receptors. In vitro functional assessment showed that GSK256471 reduced the E(Max) response induced by neurokinin B, indicating insurgable antagonist pharmacology (PA (2)=9.2). GSK256471 may be a promising candidate for the treatment of schizophrenia.

3 years

C(N(S(C)(=O)=O)C)C1=C(C(N[C@@H]([C@@H]2CC2)C3=CC=CC=C3)=O)C4=C(N=C1C5=CC=CC=C5)C=CC=C4

-20°C

12352200