GSK2646264

TargetMol Chemicals

GSK2646264

79

1398695-47-0

Chemical

GSK2646264

C24H26N2O2

374.48

GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. In addition to targeting SYK, GSK2646264 also inhibits several other kinases, including LCK, LRRK2, GSK3bèta, JAK2, VEGFR2, Aurora B, and Aurora A, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3, respectively. Notably, GSK2646264 demonstrates skin penetrability, reaching both the epidermis and dermis [1].

3 years

O(CC1=CC(C)=CC=N1)C2=C(C(OC)=CC=C2)C=3C=C4C(=CC3)CCNCC4

-20°

12352200