GSK3735967 [2170136-86-2]

TargetMol Chemicals

GSK3735967 [2170136-86-2]

999

Chemical

Research Use Only

GSK3735967

C25H31N7OS

477.62

GSK3735967 is a selective, reversible, non-nucleoside inhibitor targeting DNMT1, demonstrating an IC50 value of 40 nM. It features a planar dicyanopyridine core designed to specifically interact with DNMT1-bound hemimethylated CpG dinucleotides. Additionally, GSK3735967 possesses three binding sites, with one uniquely capable of binding to histone H4K20me3 [1] [2].

3 years

C(#N)C1=C(N=C(SCC2=CC=C(CNC(CN)=O)C=C2)C(C#N)=C1CC)N3CCN(C)CCC3

-20°C

12352200