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Gusacitinib (hydrochloride)

HY-103018A
MedChem Express
Molecular Weight496.99
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Gusacitinib (hydrochloride)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C24H29ClN8O2
  • Molecular Weight
    496.99
  • Scientific Description
    Gusacitinib (ASN-002) hydrochloride is an orally active dual SYK/JAK kinase inhibitor with IC 50 values of 5, 46, 4, 11 and 8 nM for SYK , JAK1 , JAK2 , JAK3 and TYK2 , respectively. Gusacitinib hydrochloride rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib hydrochloride can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma [1] [2] .
  • SMILES
    N#CCC1CCN(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C5C(C=NNC5=O)=N2)CC1.[H]Cl
  • UNSPSC
    12352200