GZD856

MedChem Express

GZD856

10

1257628-64-0

Research Use Only

C29H27F3N6O

532.56

GZD856 formic is a potent and orally active PDGFRalpha/beta inhibitor, with IC 50 s of 68.6 and 136.6 nM, respectively. GZD856 formic is also a Bcr-Abl T315I inhibitor, with IC 50 s of 19.9 and 15.4?nM for native Bcr-Abl and the T315I mutant. GZD856 formic has antitumor activity [1] [2] .

O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN5C(N=C4)=CC=N5)=C3

12352200