H-8 . dihydrochloride [113276-94-1]

Name: H-8 . dihydrochloride [113276-94-1]
SKU: AG-CR1-0001_A27
Price: 47 EUR
Availability: BackOrder

AG-CR1-0001

Estimated Purity>98% (NMR)

Product group Chemicals

Molecular Weight265.3 . 72.9

Overview

Supplier
AdipoGen Life Sciences
Product Name
H-8 . dihydrochloride [113276-94-1]
Delivery Days Customer
10
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous
Molecular Formula
C12H15N3O2S . 2HCl
Molecular Weight
265.3 . 72.9
Scientific Description
Chemical. CAS: 113276-94-1. Formula: C12H15N3O2S . 2HCl. MW: 265.3 . 72.9. Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Myosin light chain kinase (MLCK) inhibitor. Tool to study protein crystal structure-inhibitor interactions. - Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor [1, 2, 4]. Myosin light chain kinase (MLCK) inhibitor [3]. Tool to study protein crystal structure-inhibitor interactions [5].
SMILES
[Cl-].[Cl-].C[NH2+]CC[NH2+]S(=O)(=O)C1=CC=CC2=CN=CC=C12
Storage Instruction
2°C to 8°C
UNSPSC
12352200

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C: H. Hidaka, et al.; Biochemistry 23, 5036 (1984)
Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors: M. Inagaki, et al.; Mol. Pharmacol. 29, 577 (1986)
Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase: M. Hagiwara, et al.; Mol. Pharmacol. 31, 523 (1987)
Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives: M. Hagiwara, et al.; Mol. Pharmacol. 32, 7 (1987)
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity: R.A. Engh, et al.; J. Biol. Chem. 271, 26157 (1996)