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ProductsBack/H-89 . dihydrochloride [127243-85-0]
Chemical Structure
Chemical Structure
Chemical Structure

H-89 . dihydrochloride [127243-85-0]

Research Use Only
AG-CR1-0002
AdipoGen Life Sciences
CAS Number127243-85-0
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight446.4 . 72.9
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    H-89 . dihydrochloride [127243-85-0, 130964-39-5]
  • Delivery Days Customer
    10
  • CAS Number
    127243-85-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C20H20BrN3O2S . 2HCl
  • Molecular Weight
    446.4 . 72.9
  • Scientific Description
    Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor [1-3]. Protein kinase Cmicro (PKCmicro) inhibitor [4]. Ca2+/calmodulin-dependent protein kinase II inhibitor [2]. Casein kinase I inhibitor [2]. Myosin light chain kinase (MLCK) inhibitor [2]. Apoptosis enhancer [5]. Tool to study protein crystal structure-inhibitor interactions [6]. Rho kinase inhibitor [7]. Cell proliferation inhibitor [8]. Review [9]. - Chemical. CAS: 130964-39-5 - 127243-85-0 (free base). Formula: C20H20BrN3O2S . 2HCl. MW: 446.4 . 72.9. Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cmicro (PKCmicro) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Review.
  • SMILES
    BrC1=CC=C(C=CCNCCNS(=O)(=O)C2=C3C=CN=CC3=CC=C2)C=C1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • Polyamines differentially inhibit cyclic AMP-dependent protein kinase-mediated phosphorylation in the brain of the tobacco hornworm, Manduca sexta.: W.L. Combest et al.; J. Neurochem. 51, 1581 (1988)
  • Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12: T. Chijiwa et al.; J. Biol. Chem. 265, 5267 (1990)
  • A selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-bromocinnamyl(amino)ethyl]-5- isoquinolinesulfonamide (H-89), inhibits phosphatidylcholine biosynthesis in HeLa cells: C.C. Geilen et al.; FEBS Lett. 309, 381 (1992)
  • Characterization of activators and inhibitors of protein kinase C mu: F.J. Johannes et al.; Eur. J. Biochem. 227, 303 (1995)
  • Protein kinase A inhibitors enhance radiation-induced apoptosis: D. Findik et al.; J. Cell Biochem. 57, 12 (1995)
  • Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity: R.A. Engh et al.; J. Biol. Chem. 271, 26157 (1996)
  • The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase: J. Leemhuis, et al.; J. Pharmacol. Exp. Ther. 300, 1000 (2002)
  • H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation: D. Umeda, et al.; Eur. J. Pharmacol. 590, 61 (2008)
  • The many faces of H89: a review: A. Lochner & J.A. Moolman; Cardiovasc. Drug Rev. 24, 261 (2006)