H3B-968 [2912294-90-5]

TargetMol Chemicals

H3B-968 [2912294-90-5]

16

Chemical

Research Use Only

H3B-968

C22H18F6N4O4S

548.46

H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal activity in cancer studies, H3B-968 specifically inhibits WRNs helicase function through competitive ATP antagonism [1].

3 years

S(NCC(NC1=CC=C(CC)C=C1)=O)(=O)(=O)C=2N=C(C=C(C(F)(F)F)N2)C3=CC=C(OC(F)(F)F)C=C3

-20°C

12352200