hAChE-IN-5

TargetMol Chemicals

hAChE-IN-5

999

Chemical

Research Use Only

hAChE-IN-5

hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), showing IC50 values of 0.17 microM for both enzymes. It also potently inhibits glycogen synthase kinase 3 beta (GSK3beta) with an IC50 of 0.21 microM. Furthermore, it effectively inhibits tau protein and Abeta1-42 peptide self-aggregation, and can bind the peripheral anionic site (PAS) to prevent amyloid-beta (Abeta)-induced neurotoxicity. hAChE-IN-5s ability to cross the blood-brain barrier (BBB) supports its potential in developing multitargeted anti-Alzheimers agents [1].

3 years

-20°C

51202000