Halichondrin B [103614-76-2]

TargetMol Chemicals

Halichondrin B [103614-76-2]

999

Chemical

Research Use Only

Halichondrin B

C60H86O19

1111.31

Halichondrin B, sourced from the sponge Halichondria okadai, serves as a noncompetitive inhibitor of Vinca-alkaloid binding to tubulin, with an IC 50 for tubulin polymerization ranging from 1.2-1.4 microM, and exhibits anti-tumor activity [1].

3 years

C[C@@H]1[C@@]2(O[C@@]3(C[C@@]2(O[C@]4(C1)O[C@@]5([C@]([C@@H](C)C4)(O[C@]([C@H](C[C@H](CO)O)O)(C5)[H])[H])[H])[H])O[C@]6([C@@](C3)(O[C@@]7([C@](C6)(O[C@@]8([C@@]([C@H]7C)(OC(=O)C[C@@]9(O[C@@]%10([C@]%11([C@]%12([C@@](O[C@]%10(CC9)[H])([C@@]%13([C@](O%12)(C[C@](O%11)(O%13)CC[C@@]%14(O[C@@](CC[C@@]%15(O[C@](C8)(C(=C)[C@H](C)C%15)[H])[H])(C(=C)C%14)[H])[H])[H])[H])[H])[H])[H])[H])[H])[H])[H])[H])[H])[H])[H])[H]

-20°C

12352200