Halofuginone (lactate)
HY-N1584C
CAS Number82186-71-8
Product group Chemicals
Estimated Purity98.32
Molecular Weight504.76
Overview
- SupplierMedChem Express
- Product NameHalofuginone (lactate) [82186-71-8]
- Delivery Days Customer9
- CAS Number82186-71-8
- CertificationResearch Use Only
- Estimated Purity98.32
- Molecular FormulaC19H23BrClN3O6
- Molecular Weight504.76
- Scientific DescriptionHalofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-beta activity[3][4]. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
- SMILESOC(C(O)C)=O.O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O
- Storage Instruction-20°C
- UNSPSC12352200