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Halofuginone (lactate)

HY-N1584C
MedChem Express
CAS Number82186-71-8
Product group Chemicals
Estimated Purity98.32
Molecular Weight504.76
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Halofuginone (lactate) [82186-71-8]
  • Delivery Days Customer
    9
  • CAS Number
    82186-71-8
  • Certification
    Research Use Only
  • Estimated Purity
    98.32
  • Molecular Formula
    C19H23BrClN3O6
  • Molecular Weight
    504.76
  • Scientific Description
    Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-beta activity[3][4]. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
  • SMILES
    OC(C(O)C)=O.O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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