HaloPROTAC-E

MedChem Express

HaloPROTAC-E

10

Research Use Only

99.62

C39H56ClN5O8S

790.41

HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34 , with a DC 50 of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.

O=C(C1(CC1)C#N)N[C@@H](C(C)(C)C)C(N(C[C@@H]2O)[C@@H](C2)C(NCC(C=CC(C(SC=N3)=C3C)=C4)=C4OCCOCCOCCOCCCCCCCl)=O)=O

-20°C,2°C to 8°C

12352200