Anti-Ms CD28 Purified Low Endotoxin

EXBIO

Hamster Monoclonal to CD28 (mouse)

7

The Syrian hamster monoclonal antibody 37.51 reacts with extracellular domain of mouse CD28 costimulatory receptor, a 45 kDa homodimeric protein expressed by thymocytes, mature T cells and NK cells.

Functional application: In vitro and in vivo T cell costimulation. Flow cytometry: Recommended dilution: 6 microg / ml. Immunocytochemistry: Recommended dilution: 1-4 microg / ml. Immunoprecipitation: Recommended dilution: 1-2 microg / 100-500 microg of protein in 1 ml lysate.

Functional Assay, Flow Cytometry, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

37.51

1 mg/ml

IgG

CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

Mouse

2°C to 8°C

12352203