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Harmane (hydrochloride)

HY-101392A
MedChem Express
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Harmane (hydrochloride)
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Scientific Description
    Harmane hydrochloride is a benzodiazepine receptor inhibitor ( IC 50 =7 microM), with IC 50 values for mACh , Opioid Receptor , MAO-A/B , and alpha2-adrenergic receptor of 24 microM, 2.8 microM, 0.5 microM, 5 microM, and 18 microM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor ( IC 50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) [1] [2] [3] [4] [5] [6] .
  • UNSPSC
    12352200