Harmane (Standard)

MedChem Express

Harmane (Standard) [486-84-0]

14

Research Use Only

Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a beta-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor ( IC 50 =30 nM) over alpha2-adrenoceptor ( IC 50 =18 microM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) ( IC 50 s=0.5 and 5 microM for human MAO A/B , respectively). Harmane exhibits comutagenic effect [1] [2] [3] [4] .

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