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HCV-371

Research Use Only
T32050
TargetMol Chemicals
CAS Number675184-27-7
Product group Chemicals
Molecular Weight312.37

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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    HCV-371
  • Delivery Days Customer
    72
  • CAS Number
    675184-27-7
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    HCV-371
  • Molecular Formula
    C18H20N2O3
  • Molecular Weight
    312.37
  • Scientific Description
    HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase gamma and other unrelated viral polymerases). This indicates that it is specific for HCV polymerase. Fluorescence binding studies have shown that HCV-371 binds to NS5b at an apparent dissociation constant of 150 nM, resulting in high selectivity and non-cytotoxicity in antiviral tests.
  • Shelf life instruction
    3 years
  • SMILES
    N#CC1=CC=C(C)C2=C1C3=C([C@](OCC3)(CC(O)=O)CCC)N2
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Gopalsamy A, Lim K, Ciszewski G, Park K, Ellingboe JW, Bloom J, Insaf S, Upeslacis J, Mansour TS, Krishnamurthy G, Damarla M, Pyatski Y, Ho D, Howe AY, Orlowski M, Feld B, O'Connell J. Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6603-8. PubMed PMID: 15588095.
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