HDAC-IN-37

MedChem Express

HDAC-IN-37

10

Research Use Only

C23H24ClN7O

449.94

HDAC-IN-37 is a potent HDAC inhibitor with IC50s of 0.0551 microM, 1.24 microM, 0.948 microM and 34.2 microM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis.

CCCCNC1=C2N=CN(C2=NC(Cl)=N1)CC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O

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