HDAC11-IN-2

MedChem Express

HDAC11-IN-2

5

Research Use Only

99.52

C25H35N3O3

425.56

HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC50s of 51.1 x10-3 microM and 5 microM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylation of AMPKalpha1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver[1].

CCCCCOCCCCCNNC(C1=CC=C(CNC(C2=CC=CC=C2)=O)C=C1)=O

2°C to 8°C

12352200