HDAC6/HSP90-IN-1

MedChem Express

HDAC6/HSP90-IN-1

10

Research Use Only

C28H37N3O6

511.61

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-gamma treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice.

CC(C1=C(C=C(C(C(N2CC3=CC=C(C=C3C2)NC(CCCCCCCCC(NO)=O)=O)=O)=C1)O)O)C

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