HDAC/HSP90-IN-4

TargetMol Chemicals

HDAC/HSP90-IN-4

114

Chemical

Research Use Only

HDAC/HSP90-IN-4

C20H23N3O6

HDAC/HSP90-IN-4 significantly inhibited HDAC and HSP90 activity, with compound 20 (HDACIC50= 194 nM; HSP90alphaIC50= 153 nM) and compound 26 ((HDACIC50= 360 nM; HSP90alphaIC50= 77 nM) having the strongest HDAC and HSP90alpha inhibition. effect. Both compounds induced HSP90 expression and down-regulated HSP90 client proteins, which play an important role in the regulation of cancer cell survival and invasion.

3 years

-20°C

51202000