HDAC/Top-IN-1 [2411379-14-9]

TargetMol Chemicals

HDAC/Top-IN-1 [2411379-14-9]

114

Chemical

Research Use Only

HDAC/Top-IN-1

C29H25FN4O4

512.53

HDAC/Top-IN-1 is a broad-spectrum, orally active dual HDAC/Top inhibitor that acts on HDAC1 (IC50: 0.036 microM), HDAC2 (IC50: 0.14 microM), HDAC3 (IC50: 0.059 microM), HDAC6 (IC50: 0.089 microM) and HDAC8 ( IC50: 9.8 microM). HDAC/Top-IN-1 was able to block HEL cells in S-phase and effectively induce apoptosis.

3 years

CN1C2(C3=C(C=4C(N3)=CC=C(OCC5=CC=C(/C=C/C(NO)=O)C=C5)C4)CCN2C(=O)C=6C1=CC=C(F)C6)[H]

-20°C

51202000