ProductsBack/Hec1 (phospho Ser 55) antibody

Hec1 (phospho Ser 55) antibody

Name: Hec1 (phospho Ser 55) antibody
SKU: GTX70017_G10
Availability: BackOrder

GTX70017

ApplicationsWestern Blot

Product group Antibodies

ReactivityHuman, Mouse

TargetNDC80

Overview

Supplier
GeneTex
Product Name
Hec1 (phospho Ser 55) antibody - KO/KD, Orthogonal Validated
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.26 mg/ml
Conjugate
Unconjugated
Gene ID10403
Target name
NDC80
Target description
NDC80 kinetochore complex component
Target synonyms
HEC; HEC1; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2; KNTC2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; retinoblastoma-associated protein HEC; TID3
Host
Rabbit
Isotype
IgG
Protein IDO14777
Protein Name
Kinetochore protein NDC80 homolog
Scientific Description
HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM]
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes.
Read more
PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size.
Read more
MKLP2 functions in early mitosis to ensure proper chromosome congression.
Read more
Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity. Iemura K et al., 2021 Jul 5, J Cell Biol
Read more
SET levels contribute to cohesion fatigue. Yang L et al., 2021 Jun 15, Mol Biol Cell
Read more
SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres. Asai Y et al., 2020 Sep 24, Sci Rep
Read more
The Error-Prone Kinetochore-Microtubule Attachments During Meiosis I in Vitrified Oocytes. Gao L et al., 2020, Front Cell Dev Biol
Read more
Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere. Asai Y et al., 2019 Oct 7, J Cell Biol
Read more
PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore. Smith RJ et al., 2019 Aug 20, Cell Rep
Read more
A tension-independent mechanism reduces Aurora B-mediated phosphorylation upon microtubule capture by CENP-E at the kinetochore. Taveras C et al., 2019 Jun, Cell Cycle
Read more