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Hec1 (phospho Ser 55) antibody

Name: Hec1 (phospho Ser 55) antibody
SKU: GTX70017_G10
Availability: BackOrder

GTX70017

ApplicationsWestern Blot

Product group Antibodies

TargetNDC80

Overview

Supplier
GeneTex
Product Name
Hec1 (phospho Ser 55) antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.26 mg/ml
Conjugate
Unconjugated
Gene ID10403
Target name
NDC80
Target description
NDC80 kinetochore complex component
Target synonyms
HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80, kinetochore protein NDC80 homolog, NDC80 homolog, kinetochore complex component, NDC80 kinetochore complex component homolog, highly expressed in cancer protein, highly expressed in cancer, rich in leucine heptad repeats, kinetochore associated 2, kinetochore protein Hec1, kinetochore-associated protein 2, retinoblastoma-associated protein HEC
Host
Rabbit
Isotype
IgG
Protein IDO14777
Protein Name
Kinetochore protein NDC80 homolog
Scientific Description
HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Dong J, Jin L, Bao S, et al. Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes. Cell Discov. 2023,9(1):105. doi: 10.1038/s41421-023-00599-z
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Sobajima T, Kowalczyk KM, Skylakakis S, et al. PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. J Cell Biol. 2023,222(5). doi: 10.1083/jcb.202205117
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Schrock MS, Scarberry L, Stromberg BR, et al. MKLP2 functions in early mitosis to ensure proper chromosome congression. J Cell Sci. 2022,135(12). doi: 10.1242/jcs.259560
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Iemura K, Natsume T, Maehara K, et al. Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity. J Cell Biol. 2021,220(7). doi: 10.1083/jcb.202006116
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Yang L, Zhang Q, Niu T, et al. SET levels contribute to cohesion fatigue. Mol Biol Cell. 2021,32(13):1256-1266. doi: 10.1091/mbc.E20-12-0778
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Asai Y, Matsumura R, Hasumi Y, et al. SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres. Sci Rep. 2020,10(1):15653. doi: 10.1038/s41598-020-71955-2
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Gao L, Hou Y, Zeng S, et al. The Error-Prone Kinetochore-Microtubule Attachments During Meiosis I in Vitrified Oocytes. Front Cell Dev Biol. 2020,8:621. doi: 10.3389/fcell.2020.00621
Read this paper
Asai Y, Fukuchi K, Tanno Y, et al. Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere. J Cell Biol. 2019,218(10):3223-3236. doi: 10.1083/jcb.201811060
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Smith RJ, Cordeiro MH, Davey NE, et al. PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore. Cell Rep. 2019,28(8):2206-2219.e8. doi: 10.1016/j.celrep.2019.07.067
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Taveras C, Liu C, Mao Y. A tension-independent mechanism reduces Aurora B-mediated phosphorylation upon microtubule capture by CENP-E at the kinetochore. Cell Cycle. 2019,18(12):1349-1363. doi: 10.1080/15384101.2019.1617615
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Hec1 (phospho Ser 55) antibody

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