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ProductsBack/Hec1 (phospho Ser 55) antibody - KO/KD, Orthogonal Validated

Hec1 (phospho Ser 55) antibody - KO/KD, Orthogonal Validated

Research Use Only
GTX70017
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mammals, Mouse, Rat
TargetNDC80
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More than 130 suppliers
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Overview

  • Supplier
    GeneTex
  • Product Name
    Hec1 (phospho Ser 55) antibody - KO/KD, Orthogonal Validated
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.26 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10403
  • Target name
    NDC80
  • Target description
    NDC80 kinetochore complex component
  • Target synonyms
    HEC; HEC1; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2; KNTC2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; retinoblastoma-associated protein HEC; TID3
  • Host
    Rabbit
  • Isotype
    IgG
  • Modification Type
    Phosphorylated
  • Scientific Description
    HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM]
  • Reactivity
    Human, Mammals, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity. Iemura K et al., 2021 Jul 5, J Cell Biol
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  • SET levels contribute to cohesion fatigue. Yang L et al., 2021 Jun 15, Mol Biol Cell
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  • SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres. Asai Y et al., 2020 Sep 24, Sci Rep
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  • The Error-Prone Kinetochore-Microtubule Attachments During Meiosis I in Vitrified Oocytes. Gao L et al., 2020, Front Cell Dev Biol
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  • Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere. Asai Y et al., 2019 Oct 7, J Cell Biol
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  • PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore. Smith RJ et al., 2019 Aug 20, Cell Rep
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  • A tension-independent mechanism reduces Aurora B-mediated phosphorylation upon microtubule capture by CENP-E at the kinetochore. Taveras C et al., 2019 Jun, Cell Cycle
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  • Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis. Nguyen AL et al., 2018 Nov 5, Curr Biol
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  • Tension-Induced Error Correction and Not Kinetochore Attachment Status Activates the SAC in an Aurora-B/C-Dependent Manner in Oocytes. Vallot A et al., 2018 Jan 8, Curr Biol
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  • An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint. Qian J et al., 2017 Nov 16, Mol Cell
    Read more