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ProductsBack/Heliquinomycin [178182-49-5]
Chemical Structure
Chemical Structure
Chemical Structure

Heliquinomycin [178182-49-5]

Research Use Only
AG-CN2-0091
AdipoGen Life Sciences
CAS Number178182-49-5
DownloadMSDS
Product group Chemicals
Estimated Purity>80%
Molecular Weight698.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Heliquinomycin [178182-49-5]
  • Delivery Days Customer
    10
  • CAS Number
    178182-49-5
  • Certification
    Research Use Only
  • Estimated Purity
    >80%
  • Hazard Information
    Warning
  • Molecular Formula
    C33H30O17
  • Molecular Weight
    698.6
  • Scientific Description
    Antibiotic [1]. DNA helicase inhibitor [1]. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex [3, 4]. Topoisomerase I and II inhibitor (weaker than DNA helicase) [2]. DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis [2]. Induces cell cycle arrest [2]. Anticancer compound [1, 2]. Antibacterial against Gram-positive bacteria [1]. - Chemical. CAS: 178182-49-5. Formula: C33H30O17. MW: 698.6. Isolated from Streptomyces sp. MJ929-SF2. Antibiotic. DNA helicase inhibitor. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. Topoisomerase I and II inhibitor (weaker than DNA helicase). DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis. Induces cell cycle arrest. Anticancer compound. Antibacterial against Gram-positive bacteria.
  • SMILES
    COC1CC(O[C@@H]2C3=C(O[C@@]22OC4=C(C[C@H]2O)C=C2C=C(OC(=O)C2=C4O)C(=O)OC)C(O)=C2C(=O)C(OC)=CC(=O)C2=C3O)OC(C)C1O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities: M. Chino, et al.; J. Antibiot. 49, 752 (1996)
  • Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth: M. Chino, et al.; J. Antibiot. 51, 480 (1998)
  • Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase: Y. Ishimi, et al.; FEBS J. 276, 3382 (2009)
  • Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase: T. Sugiyama, et al.; J. Biochem. 151, 129 (2012)