HEMTAC CDK4/6 degrader 1 [2821803-61-4]

TargetMol Chemicals

HEMTAC CDK4/6 degrader 1 [2821803-61-4]

999

Chemical

Research Use Only

HEMTAC CDK4/6 degrader 1

C48H53ClN16O4

953.49

HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a \( K_d \) value of 35.7 microM. It induces CDK4/6 degradation in B16F10 melanoma cells, arrests the cell cycle at the G0/G1 phase, and induces apoptosis. HEMTAC CDK4/6 degrader 1 can be used in cancer research [1].

3 years

O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCN(CC(NCC5=CN(CCC#CC=6C=7C(N(CC8=C(C)C(OC)=C(C)C=N8)C6)=NC(N)=NC7Cl)N=N5)=O)CC4)N2)C9CCCC9

-20°C

51202000