![Hepatocyte Specific(CPS1/1022), CF640R conjugate, 0.1mg/mL [26628-22-8] Hepatocyte Specific(CPS1/1022), CF640R conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2016/12/BNUB1022-0-1.jpg)
Hepatocyte Specific(CPS1/1022), CF640R conjugate, 0.1mg/mL [26628-22-8]
BNC401022
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Canine, Human, Mouse
TargetCPS1
Overview
- SupplierBiotium
- Product NameHepatocyte Specific(CPS1/1022), CF640R conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCPS1/1022
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID1373
- Target nameCPS1
- Target descriptioncarbamoyl-phosphate synthase 1
- Target synonymscarbamoyl-phosphate synthase (ammonia); carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthase 1, mitochondrial; carbamoylphosphate synthetase I; CPSASE1; GATD6; PHN
- HostMouse
- IsotypeIgG1
- Protein IDP31327
- Protein NameCarbamoyl-phosphate synthase [ammonia], mitochondrial
- Scientific DescriptionThis MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Canine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203