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Hepatocyte Specific(CPS1/1022), CF640R conjugate, 0.1mg/mL [26628-22-8]

Hepatocyte Specific(CPS1/1022), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC401022
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Canine, Human, Mouse
TargetCPS1
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Overview

  • Supplier
    Biotium
  • Product Name
    Hepatocyte Specific(CPS1/1022), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CPS1/1022
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID1373
  • Target name
    CPS1
  • Target description
    carbamoyl-phosphate synthase 1
  • Target synonyms
    carbamoyl-phosphate synthase (ammonia); carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthase 1, mitochondrial; carbamoylphosphate synthetase I; CPSASE1; GATD6; PHN
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP31327
  • Protein Name
    Carbamoyl-phosphate synthase [ammonia], mitochondrial
  • Scientific Description
    This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Canine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203