HER2 Antibody / ErbB2

Biorbyt

HER2 Antibody / ErbB2

16

Flow Cytometry

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 0.5-1ug/ml FACS, IF, IHC-P

Research Use Only

ERBB2/2452

IgG

Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This mAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

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