HEY1 Antibody, FITC conjugated

Cusabio

HEY1 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

HEY1

hes related family bHLH transcription factor with YRPW motif 1

basic helix-loop-helix protein OAF1; BHLHb31; cardiovascular helix-loop-helix factor 2; CHF2; class B basic helix-loop-helix protein 31; hairy and enhancer of split-related protein 1; hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; hairy-related transcription factor 1; HERP2; HESR1; HES-related repressor protein 1; HES-related repressor protein 2; hHRT1; HRT-1; NERP2; OAF1

Rabbit

IgG

Hairy/enhancer-of-split related with YRPW motif protein 1

Transcriptional repressor which binds preferentially to the canonical E box sequence 5-CACGTG-3 (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).

Human

-20°C or -80°C

12352203