HFE2 antibody, N-term

GeneTex

HFE2 antibody, N-term

9

WB: 0.2-2.5 ug/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.5-1 mg/ml

Unconjugated

HJV

hemojuvelin BMP co-receptor

haemojuvelin; hemochromatosis type 2 (juvenile); hemochromatosis type 2 protein; hemojuvelin; hemojuvelin BMP coreceptor; HFE2; HFE2A; JH; repulsive guidance molecule c; RGM domain family member C; RGMC

Rabbit

IgG

Hemojuvelin

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5 UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]

Human

-20°C or -80°C,2°C to 8°C

12352203