HG-7-85-01 [1258391-13-7]

TargetMol Chemicals

HG-7-85-01 [1258391-13-7]

999

1258391-13-7

Chemical

Research Use Only

HG-7-85-01

C31H31F3N6O2S

608.68

HG-7-85-01 is a type II ATP competitive inhibitor targeting wild-type and gatekeeper mutations of Bcr-Abl, PDGFRalpha, Kit, and Src kinases. It effectively inhibits T315I mutant Bcr-Abl kinase, as well as KDR and RET kinases with IC50 values of 3 nM, 20 nM, and 30 nM, respectively. HG-7-85-01 exhibits weak or no inhibition towards other kinases (IC50 >2 microM). Additionally, this compound inhibits cell proliferation by inducing apoptosis and impeding cell-cycle progression.

3 years

CCN1CCN(Cc2ccc(NC(=O)c3cccc(c3)-c3ccc4nc(NC(=O)C5CC5)sc4n3)cc2C(F)(F)F)CC1

-20°C

12352200