HIF-1 alpha (556-574) [1201633-99-9]

TargetMol Chemicals

HIF-1 alpha (556-574) [1201633-99-9]

9

1201633-99-9

Research Use Only

C101H150D2N20O34S2

2254.6

HIF-1 alpha (556-574) is a hypoxia-inducible factor-1 19-mer fragment. HIF-1 functions as a master regulator of oxygen homeostasis by initiating hypoxia-induced gene expression when the HIF-1 subunit is stabilized due to lack of oxygen. This fragment binds to the von Hippel-Lindau factor (VHL), an E3 ubiquitin ligase, with proline 564 being essential to the binding process.

C([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CC(C)C)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CCSC)=O)CC(C)C)=O)C)=O)C[C@@H]([C@@H]1[2H])[2H])CC2=CC=C(O)C=C2)=O)[C@H](CC)C)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCC(N)=O)=O)=O)CC(O)=O)=O)CC(O)=O)=O)CC(O)=O)=O)CCSC)=O)CCC3

-20°C

12352200