HIF1AN Antibody, HRP conjugated

Cusabio

HIF1AN Antibody, HRP conjugated

20

ELISA

Research Use Only

Polyclonal

HRP

HIF1AN

hypoxia inducible factor 1 subunit alpha inhibitor

factor inhibiting HIF1; factor inhibiting HIF-1; FIH1; FIH-1; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase

Rabbit

IgG

Hypoxia-inducible factor 1-alpha inhibitor

Hydroxylates HIF-1 alpha at \Asp-803\ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Human

-20°C or -80°C

12352203