HIPK3 Antibody, Biotin conjugated

Cusabio

HIPK3 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

HIPK3

homeodomain interacting protein kinase 3

DYRK6, FIST3, PKY, YAK1, homeodomain-interacting protein kinase 3, ANPK, FIST, androgen receptor-interacting nuclear protein kinase, fas-interacting serine/threonine-protein kinase, homolog of protein kinase YAK1

Rabbit

IgG

Homeodomain-interacting protein kinase 3

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Human

-20°C or -80°C

41116161